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I'm unable to send email Articles
If you are able to receive mail, but unable to send, the problem is most likely that your ISP is restricting port 25 in an effort to combat spam. Port 25 is the port on your system used to send e-mail, and "ISP" refers to your Internet Service Provider (for example, Comcast, SBC Global, or Cox to name a few).

The resolution to this problem is simple. You will need to change your outgoing server setting to your ISP's SMTP server:
-OR-
You can simply change your SMTP port to 2525.  This will override the blocked SMTP port (25). 

How to change your outgoing mail server to use your ISP:

In your mail client (MS Outlook) replace your "outgoing" mail server (mail.YourDomain.com) with that of your ISP (for example: mail.earthlink.net). If you do not know what your ISP's outgoing mail server setting is, contact their customer support to request this information.